Ectopic ACTH syndrome: diagnostic and therapeutic challenge
نویسندگان
چکیده
منابع مشابه
[Ectopic ACTH syndrome].
Cushing症 候群 は慢性的なコルチゾール過剰症であ り,放 置すると脳血管障害,糖 尿病,感 染症などで死 亡する.し たがって,適 切な診断 と治療が重要である. 表1に 示すように,ACTH依 存性Cushing症 候群 に は脳下垂体のACTH産 生腫によるGushing病 と異所 性ACTH症 候群があ り,ACTH非 依存性Cushing 症候群 には副腎原発性病変,医 原性 によるCushing症 候群がある.中 で もGushing病 と異所性ACTH症 候 群の鑑別 は治療法の選択 と関連 して重要である.我 々 が経験 した異所性ACTH症 候群を紹介する. 【症例】64歳,女 性.1993年 頃か ら顔面,下 腿の浮 腫,し びれ感 と全身の疼痛(肩 甲部,胸 部,腰 背部) を自覚するようになったため某院に入院した.糖 尿病, 高血圧,骨 粗鬆症 と診断さ...
متن کاملEctopic ACTH syndrome.
Ectopic adrenocorticotropic secretion (EAS) is responsible for 12-17% of cases of Cushing's syndrome (CS) and covers a range of tumours, from undetectable benign lesions to widespread metastases. The syndrome is often associated with severe hypercortisolaemia, which aggravates the underlying condition. EAS requires a complete workup that includes the establishment of endogenous CS, diagnosis of...
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The classic symptoms of ectopic pregnancy are secondary amenorrhoea, abdominal pain and vaginal haemorrhage, with a clinical picture of varying acuteness. It is among the commonest causes of maternal mortality during the first three months of pregnancy. In the majority of cases (95%) the pregnancy is tubal, but other sites are possible (cervical, corneal, ovarian, peritoneal). In the treatment ...
متن کاملEctopic ACTH syndrome: clinicopathological correlations.
Ten out of 164 cases of bronchogenic carcinoma showed pathological evidence at necropsy of the ectopic ACTH syndrome. All occurred in association with oat-cell carcinoma, constituting 19% of that group. The pathological features consisted of adrenocortical hyperplasia confined to the zona fasciculata and Crooke's hyaline change in the pituitary. Immunoperoxidase stainable ACTH was detected in t...
متن کاملEctopic ACTH syndrome: redefinition and case report.
A case is reported which supports the principle that ACTH precursors best characterise so-called ectopic ACTH-syndrome, which should therefore more accurately be referred to as ectopic ACTH-precursor syndrome.
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2015
ISSN: 1479-6848
DOI: 10.1530/endoabs.37.ep1316